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KMID : 0602619980040040330
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Korean Journal of Hepatology
1998 Volume.4 No. 4 p.330 ~ p.345
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Effectiveness of Early Detection among the High Risk Group of Hepatocellular Carcinoma by Ultrasound Screening Test
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Abstract
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Background/Aims: The prognosis of primary hepatocellular carcinoma is extremely poor because of its large size, portal vein thrombosis, extrahepatic metastasis and underlying liver cirrhosis. The aim of this study is to evaluate the usefulness of ultrasound screening test for early detection of hepatocellular carcinoma in high-risk populations. Methods: We analysed 119 patients who were diagnosed with hepatocellular carcinoma by ultrasonography screening test in Yonsei University. Severance Hospital from the period of January 1990 to December 1996. Results: The mean follow-up duration to the diagnosis of hepatocellular carcinoma was 30 months (range 3-75). The number of patients with single lesion was 89 (75%). The mean diameter of the tumor was 3.0 cm (range 1-10), 82 patients (70%) had masses measured less than 3 cm in diameter. The number of patients with elevated serum alphafetoprotein level above 400 ng/ml was 29 (25%). The median survival was 28 months in screening group, significant compared with 7 months in control group (p<0.001). Conclusions: Ultrasound follow-up in high-risk group of hepatocellular carcinoma made it possible to detect small tumors in a high percentage of cases. This may lead to an increase in the number of potentially curable tumors and hence an increase in the overall survival rate. So ultrasound screening test is important in the high-risk group of hepatocellular carcinoma. (Korean J Hepatol 1998;4:330?345)
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